The One Chicago universe is a juggernaut of network television. With Chicago Med, Chicago Fire, and Chicago P.D. continuing to dominate NBC’s primetime schedule, the franchise enters Fall 2025 with momentum — and mystery. The 2024-2025 seasons left viewers with jaw-dropping finales, shocking character exits, and cliffhangers that have fans counting down the days until the next premiere. As we head into a new fall season, the burning questions are piling up. From lingering medical emergencies to unresolved personal dramas and potential shake-ups in all three series, the stakes have never been higher. Here are 10 of the most pressing questions fans want answered when the One Chicago universe returns in Fall 2025.
Dr. Crockett Marcel’s struggle with guilt and grief over recent losses has been palpable. Last season ended with him walking away from the OR after a tragic outcome left him questioning everything. Will Crockett find his way back to medicine — or is this the end of the road for one of Med’s most compelling characters? Dean Archer’s position at Chicago Med has never been completely secure, but the tension between him and Sharon Goodwin has reached a boiling point. After repeated clashes over ethics and procedure, could this be the season that finally pushes him out of Gaffney Medical Center?
After seasons of will-they-won’t-they, Sylvie Brett and Matt Casey finally tied the knot. But with Casey’s return to Portland looming and Brett questioning her place in Chicago, fans are wondering: Will these two get their happily ever after, or is a long-distance heartbreak just around the corner? Stella Kidd has climbed the ranks and now finds herself shouldering more responsibility than ever before. But after some early stumbles and doubts from those around her, can she prove she’s got what it takes to lead — especially with so many eyes watching her next move?
With shifting roles, retirements, and exits, Firehouse 51 may be in need of a new lieutenant this fall. Will a current firefighter rise to the occasion, or are we about to see a new face enter the dynamic crew? This question is especially pressing with rumors swirling about personnel changes behind the scenes. The last few seasons have seen fewer One Chicago crossover events due to scheduling issues and pandemic-era restrictions. But fans are hungry for those high-stakes, interconnected storylines that bring Med, Fire, and P.D. together. Will Fall 2025 be the return of the epic crossover?
Let’s be honest — the One Chicago shows don’t shy away from heartbreak. Whether it’s an unexpected death, a surprise exit, or a devastating injury, these series know how to pull the rug out from under fans. With multiple characters on shaky ground and teaser trailers hinting at chaos, one big question looms: Who won’t make it to the midseason break?
The One Chicago universe has mastered the art of balancing medical drama, heroic firehouse action, and gritty police work with deeply emotional storytelling. As we approach the Fall 2025 premieres, the questions above are more than just plot points — they reflect years of investment fans have made in the journeys of these characters. Whether you’ve been watching since Season 1 or just recently dove into the franchise, there’s no denying that Med, Fire, and P.D. have cemented their place as network TV staples. This fall promises big answers, bigger emotions, and possibly the most transformative season yet.a
