Every Friday night for 14 seasons, fans were greeted with the familiar faces of the Reagan family—Tom Selleck’s Frank, Donnie Wahlberg’s Danny and Bridget Moynahan’s Erin—but once in a while, a few new faces would pop into the mix. Whether that be an old, reliable friend or a new foe, you can bet that the NYPD family knew quite a few New Yorkers.
From Everwood’s Treat Williams to Frasier’s Bebe Neuwirth, see which of your favorite celebrities have made a cameo in the beloved crime drama!
Treat Williams
Seeing this Hair star in the middle of New York City certainly was a treat! Treat Williams had a recurring role in Blue Bloods as Lenny Ross, the best friend of Police Commissioner Frank Reagan. Williams appeared in six episodes between 2016 and 2023, and when the actor died in 2023, they said a proper goodbye to him.
In the series, it was revealed that Ross had died of cancer, which he was diagnosed with in an earlier episode. Williams previously reflected on his time on the series.
“I gotta tell you, what an honor,” Williams said of being able to join a family dinner. “Two hundred episodes, nobody ever ate dinner with the family but me, and I was really, really honored that day that they invited me to the table.”
Lori Loughlin
Lori Loughlin, best known for her role in Full House, appeared on two episodes of Blue Bloods. The actress starred as Grace Edwards, the wife of a police officer who was killed, in the 7th season. In response, she met with Frank in hopes of keeping her son out of the NYPD, fearful of the same thing happening to him.

Loughlin made a second appearance in 2024 as the same character, who was actively keeping Frank’s son, Danny, from receiving an award for his work as a detective.
Bebe Neuwirth
Bebe Neuwirth, best known for her role as Dr. Lilith Crane on Cheers, had a lengthy guest spot on Blue Bloods. From 2013 to 2019, Neuwirth starred as Kelly Peterson, the Inspector General who was often a foe to Frank. At the same time, the two characters had some serious chemistry, leaving fans wondering if there was something else going on.
Whoopi Goldberg
Whoopi Goldberg made three separate appearances between 2016 and 2020 as Regina Thomas, City Council Speaker, who often squabbled with Frank over police policy and politics. Her character tended to rock the boat and faced off with the commissioner about hot topics like police brutality.